A novel copper complex of 3-benzoyl-α methyl benzene acetic acid with antitumor activity mediatedviacyclooxygenase pathway
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چکیده
منابع مشابه
1-Benzoyl-3-methyl-3-pentylthiourea
Two independent mol-ecules comprise the asymmetric unit of the title compound, C(14)H(20)N(2)OS. These differ in the relative orientations of the pentyl chains [C-C-C-C torsion angles = -176.7 (3) and 176.4 (3)°]. Significant twists are evident in each mol-ecule, the dihedral angles formed between the thio-urea and amide residues being 53.47 (17) and 55.81 (17)°. In the crystal, each mol-ecule ...
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In the present study, 2-pyridinecarboxaldehyde 2-pyridinecarboxylic acid hydrazone (PPAH) was prepared and its antitumor activity was evaluated. The inhibition of proliferation of PPAH against the HepG2 and HCT-116 cell lines was less effective, yet in the presence of copper ions, the mixture demonstrated excellent antitumor activity (IC50 at 2.75±0.30 µM for the HepG2 cell line, and 1.90±0.20 ...
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In our study, we aimed to synthesize novel grafted hyaluronic acid with cationic biodegradable polymer, poly (N-vinyl imidazole) (PVI), through free radical polymerization using potassium persulfate as initiator. The effect of various grafting factors including initiator and monomer concentrations, reaction time and temperature was studied on the percentage of grafting parameters such as; graft...
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A square planar copper complex of derivatized NSAID drug (Ketoprofen thiosemicarbazone [3-benzoyl-alpha-methyl benzene acetic acid thiosemicarbazone]), is characterized by elemental analysis, spectroscopy, electrochemistry and magnetic susceptibility studies which exhibits dose-dependent and enhanced antiproliferative effects on human breast cancer cell line T47D rich in progesterone receptors.
متن کامل2-(6-Benzoyl-2-oxo-1,3-benzothiazol-3-yl)acetic acid
In the title compound, C(16)H(11)NO(4)S, the nine-membered fused ring is nearly planar, with maximum deviations from the mean plane of -0.022 (1) Å for the N atom and 0.011 (1) Å for the S atom, and makes a dihedral angle of 53.56 (7)° with the phenyl ring. The crystal structure is stabilized by O-H⋯O and C-H⋯O hydrogen-bonding inter-actions.
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2006
ISSN: 0020-7136
DOI: 10.1002/ijc.22383